cardiac myosin การใช้

The first genetic mutation ( in cardiac myosin binding protein C ) responsible for feline HCM was discovered in 2005 in Maine Coon cats.
Approximately 45 % of these mutations occur in the ? myosin heavy chain gene on chromosome 14 q11.2-3, while approximately 35 % involve the cardiac myosin binding protein C gene.
Phosphorylation of cardiac myosin heavy chains ( see MYH7B ) and light chains ( see MYL2 ) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.
Although he and his team were unable to establish the precise function of regulatory light chains in vertebrate skeletal and cardiac myosins, it laid the foundation for a whole new field of regulation of how phosphorylation regulates movement in smooth muscle and in non-muscle cells.
The cardiac myosin binding protein C mutation identified in Maine Coon cats has not been found in any other breed of cat with HCM, but more recently another myosin binding protein C mutation has been identified in Ragdoll cats with HCM . As in humans, feline HCM is not present at birth but develops over time.